Third COVID-19 Dose for Immunocompromised Available

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Source: Santa Barbara County Public Health Department

What You Need to Know

  • People with moderately to severely compromised immune systems are especially vulnerable to COVID-19, and may not build the same level of immunity to 2-dose vaccine series compared to people who are not immunocompromised.
  • This additional dose intended to improve immunocompromised people’s response to their initial vaccine series.
  • Although CDC does not recommend additional doses or booster shots for any other population at this time, HHS has announced a plan to begin offering COVID-19 vaccine booster shots this fall.
  • CDC recommends that people with moderately to severely compromised immune systems receive an additional dose of mRNA COVID-19 vaccine at least 28 days after a second dose of Pfizer-BioNTech COVID-19 vaccine or Moderna COVID-19 vaccine.

Data on Decreased Immune Response Among Immunocompromised People

  • People who are moderately to severely immunocompromised make up about 3% of the adult population and are especially vulnerable to COVID-19 because they are more at risk of serious, prolonged illness.
  • Studies indicate some immunocompromised people don’t always build the same level of immunity after vaccination the way non-immunocompromised people do, and may benefit from an additional dose to ensure adequate protection against COVID-19. In small studies, fully vaccinated immunocompromised people have accounted for a large proportion of hospitalized “breakthrough cases,” and that suggests immunocompromised people are more likely to transmit the virus to household contacts.

Who Needs an Additional COVID-19 Vaccine?

  • Currently, CDC is recommending that moderately to severely immunocompromised people receive an additional dose. This includes people who have:
    • Been receiving active cancer treatment for tumors or cancers of the blood
    • Received an organ transplant and are taking medicine to suppress the immune system
    • Received a stem cell transplant within the last 2 years or are taking medicine to suppress the immune system
    • Moderate or severe primary immunodeficiency (such as DiGeorge syndrome, Wiskott-Aldrich syndrome)
    • Advanced or untreated HIV infection
    • Active treatment with high-dose corticosteroids or other drugs that may suppress your immune response
  • People should talk to their healthcare provider about their medical condition, and whether getting an additional dose is appropriate for them.

Find a COVID-19 Vaccine

  • Contact your regular healthcare provider.
  • Find a COVID-19 Vaccine: Search vaccines.gov, text your ZIP code to 438829, or call 1-800-232-0233 to find locations near you.
  • Check your local pharmacy’s website to see if vaccination walk-ins or appointments are available.

Vaccine Card and Any Additional Dose

  • At your first vaccination appointment, you should have received a vaccination card that tells you what COVID-19 vaccine you received, the date you received it, and where you received it. Bring this vaccination card to your additional dose vaccination appointment.
  • If you did not receive a COVID-19 vaccination card at your first appointment, contact the vaccination provider site where you got your first shot or your state health department to find out how you can get a card.
    • If you have lost your vaccination card or don’t have a copy, contact your vaccination provider directly to access your vaccination record.
    • If you cannot contact your vaccination provider directly, contact your state health department’s immunization information system (IIS). You can find state IIS information on the CDC website. Vaccination providers are required to report COVID-19 vaccinations to their IIS and related systems.
    • If you enrolled in v-safe or VaxText after your first vaccine dose, you can access your vaccination information using those tools.
    • If you have made every effort to locate your vaccination information, are unable to get a copy or replacement of your vaccination card, and still need an additional dose, talk to a vaccination provider.
  • Bring your vaccination card with you to your additional dose appointment so your provider can fill in the information about your additional dose.
  • Keep your vaccination card in case you need it for future use. Consider taking a picture of your vaccination card after your second shot appointment as a backup copy.
  • CDC does not maintain vaccination records or determine how vaccination records are used, and CDC does not provide the CDC-labeled white COVID-19 vaccination record card to people. These cards are distributed to vaccination providers by state health departments.
  • Please contact your state health department if you have additional questions about vaccination records. Your local or state health department can also provide more information about the laws or regulations in your area.

Frequently Asked Questions

How long after getting my initial COVID-19 vaccines can I get an additional dose?

Can you mix and match the vaccines?

  • For people who received either Pfizer-BioNTech or Moderna’s COVID-19 vaccine series, a third dose of the same mRNA vaccine should be used. A person should not receive more than three mRNA vaccine doses. If the mRNA vaccine product given for the first two doses is not available or is unknown, either mRNA COVID-19 vaccine product may be administered.

What should immunocompromised people who received the J&J/Janssen vaccine do?

  • The FDA’s recent EUA amendment only applies to mRNA COVID-19 vaccines, as does CDC’s recommendation.
  • Emerging data have demonstrated that immunocompromised people who have low or no protection following two doses of mRNA COVID-19 vaccines may have an improved response after an additional dose of the same vaccine. There is not enough data at this time to determine whether immunocompromised people who received the Johnson & Johnson’s Janssen COVID-19 vaccine also have an improved antibody response following an additional dose of the same vaccine.

What are the benefits of people receiving an additional vaccine dose?

  • An additional dose may prevent serious and possibly life-threatening COVID-19 in people who may not have responded to their initial vaccine series. In ongoing clinical trials, the mRNA COVID-19 vaccines (Pfizer-BioNTech or Moderna) have been shown to prevent COVID-19 following the two-dose series. Limited information suggests that immunocompromised people who have low or no protection after two doses of mRNA vaccines may have an improved response after an additional dose of the same vaccine.

What are the risks of vaccinating individuals with an additional dose?

  • There is limited information about the risks of receiving an additional dose of vaccine, and the safety, efficacy, and benefit of additional doses of COVID-19 vaccine in immunocompromised people continues to be evaluated. So far, reactions reported after the third mRNA dose were similar to that of the two-dose series: fatigue and pain at injection site were the most commonly reported side effects, and overall, most symptoms were mild to moderate.
  • However, as with the two-dose series, serious side effects are rare, but may occur.
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17 Comments

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a-1631585202 Sep 13, 2021 07:06 PM
Third COVID-19 Dose for Immunocompromised Available

"An additional dose may prevent serious and possibly life-threatening COVID-19 in people who may not have responded to their initial vaccine series." What kind of response should there have been to the initial first and second shots?

a-1631585797 Sep 13, 2021 07:16 PM
Third COVID-19 Dose for Immunocompromised Available

A normal immune system response would have been a buildup of antibodies and priming of the cellular immune system components to fight the virus. However, in people with compromised immune systems and older people, the response may have been too weak or short-lived.

Cadillackid Sep 13, 2021 11:01 AM
Third COVID-19 Dose for Immunocompromised Available

I got my vaccines but I don’t care if other people don’t, why are people getting so mad if you do or don’t? This world is weird, stop
Being weird, that’ll be cool

PattersonPerson Sep 20, 2021 03:36 PM
Third COVID-19 Dose for Immunocompromised Available

The continued restrictions come from our brave and valiant leaders who are following marching orders in order to keep their high positions requiring careful consistent management of social cohesion. Not from the holdouts.

Restrictions, like covid, will continue no matter who does or does not take another shot.

PattersonPerson Sep 20, 2021 12:42 PM
Third COVID-19 Dose for Immunocompromised Available

Cadillac Kid, you need to get with the narrative. The narrative says all unvaxxed people are
--reckless
--selfish
--superspreaders
--dangerous to be near
--taking up ALL hospital beds
--have had both shots but it's still less than 14 days after 2nd shot, so they are still inn the dangerous unvaccinated category and when hospitalized after 2nd shot they are UNVACCINATED STATUS and should be demonized as taking up precious hospital beds
--the reason we cannot go back to 'normal'
--not to be trusted with anything at all, as they are misinformed by alternative media
--should not be able to have any medical care whatsoever when they get covid and DIE
--will definitely DIE because they didn't get vaccinated!!
--have no right to share the same space as the honorable vaccinated share
--just. plain. evil.

dukemunson Sep 15, 2021 06:47 AM
Third COVID-19 Dose for Immunocompromised Available

The problem is that people on the far left and far right have no grasp of reality when it comes to Covid-19. It’s wildly different than polio and we obviously aren’t vaccinating our way out it, it’s here to stay in a much different capacity than polio. That you do t realize that speaks to how divorced from reality so many people on both fringes are…

dukemunson Sep 14, 2021 09:16 PM
Third COVID-19 Dose for Immunocompromised Available

You do realize that polio and Covid are completely different though, right? And that every one agrees that Covid is here to stay no matter what…doesn’t matter what the vaccine rate it’s… it’s endemic…

a-1631637874 Sep 14, 2021 09:44 AM
Third COVID-19 Dose for Immunocompromised Available

A-1631635729, Whether or not the political elites want me to do or not do something, I am intelligent enough to know that when nurse friends tell me that over 90% of their hospital ICU patients re unvaccinated covid cases then there is something wrong.

I am all for freedom of choice. But if people want to go unvaccinated then they should stay in their homes and not interact with the public.

When I was in high school in the '50s, we periodically had bouts of polio going around. I had several classmates that had it and they were severely impacted - iron lungs, deaths. When the first vaccine was invented we were all given it - no questions asked. And you know what? polio is now a thing of the past. So stop being foolish and get with the medical science.

a-1631635191 Sep 14, 2021 08:59 AM
Third COVID-19 Dose for Immunocompromised Available

Cadillac, The problem with a lot of people refusing to be vaccinated is that it prolongs the pandemic which results in continued restrictions on everyone. AND, even if you have been vaccinated you can still be infected although hopefully only a mild case.

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